报告题目:Precision plant breeding using genome editing techniques
报告人:高彩霞 研究员
报告时间:2015年12月11日下午15:30
报告地点:禧强楼报告厅
主办单位:海峡联合研究院基因组中心
园艺植物生物工程研究所
报告人简介:
高彩霞博士,研究员,博士生导师。1997年,获中国农业大学农学博士。1997-1998年,在丹麦DLF-Trifolium公司科研部博士后。1998-2009年丹麦DLF-Trifolium公司科研部Research Scientist,课题组长。2009年9月回国,在遗传发育所植物细胞与染色体工程国家重点实验室任研究员,课题组长,2010年入选中国科学院“杰出技术人才”。主要从事重要农作物基因组定向编辑技术方法的研究与应用、农作物遗传转化技术体系的建立与应用,以及小麦、玉米等重要基因的功能解析及基因组编辑定向设计分子育种研究。并负责所生物技术平台的建设与管理。回国六年,以通讯作者身份在Nature Biotechnology、Nature Plants、Nature Protocols、PLOS Biology、Molecular Plant、Plant Biotechnology Journal等期刊发表学术论文多篇。
代表论文(*通讯作者):
1. Ji X1, Zhang H1, Zhang Y, Wang Y, Gao C* (2015) Establishing a CRISPR-Cas-like immue system conferring DNA virus resistance in plants. Nature Plants, doi: 10.1038/nplants.2015.144. (1 co-first authors).
2. Shan Q, Zhang Y, Chen K, Zhang K & Gao C* (2015) Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology. Plant Biotechnology Journal, 13, 791-800.
3. Shan Q, Wang Y, Li J, Gao C*(2014) Genome editing in rice and wheat using the CRISPR/Cas system. Nature Protocols, 9, 2395-2410.
4. Gao C* (2015) Genome editing in crops: from bench to field. National Science Review, 2, 13-15.
5. Wang Y1, Cheng X1, Shan Q, Zhang Y, Liu J, Gao C*, Qiu J * (2014) Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotechnology, 32, 947-951. (1 co-first authors) (Recommended in F1000Prime).
6. Voytas D F*, Gao, C* (2014) Precision genome engineering and agriculture: opportunities and regulatory challenges. PLoS Biology, 12, e1001877.
7. Liang Z, Zhang K, Chen K, Gao C* (2014) Targeted Mutagenesis in Zea mays Using TALENs and the CRISPR/Cas System.Journal of Genetics and Genomics, 41, 63-68.
8. Chen K, Shan Q, Gao C* (2014) An efficient TALEN mutagenesis system in rice. Methods, 69, 2-8.
9. Chen K, Gao C* (2014) Targeted genome modification technologies and their applications in crop improvements. Plant Cell Reorts, 33:575-583.
10. 李君, 张毅, 陈坤玲, 单奇伟, 王延鹏, 梁振, 高彩霞* (2013) CRISPR/Cas系统:RNA靶向的基因组定向编辑新技术. 遗传. 35(11): 1-9.
11. Shan Q1, Wang Y1, Li J1, Zhang Y, Chen K, Liang Z, Zhang K, Liu J, Qiu J*, Gao C* (2013) Targeted genome modification of crop plants using a CRISPR-Cas system. Nature Biotechnology, 31, 686-688. (1 co-first authors).
12. Chen K, Gao C* (2013) TALENs: Customizable Molecular DNA Scissors for Genome Engineering of Plants.Journal of Genetics and Genomics, 40(6): 271-279.
13. Shan Q1, Wang Y1, Chen K1, Liang Z, Li J, Zhang Y, Zhang K, Liu J, Voytas D F, Zheng X, Zhang Y*, Gao C* (2013) Rapid and efficient gene modification in rice and Brachypodium using TALENs. Molecular Plant, 6, 1365-1368. (1co-first authors).
14. Long D, Wu X, Yang Z, Lenk I, Nielsen K, Gao C* (2011) Comparison of three selectable marker genes for transformation of tall fescue (Festuca arundinacea Schreb.) plants by particle bombardment. In Vitro Cell Dev. Biol. Plant, 47, 658-666.